Microsecond-Scale Timing Precision in Rodent Trigeminal Primary Afferents
Identifieur interne : 000734 ( Main/Exploration ); précédent : 000733; suivant : 000735Microsecond-Scale Timing Precision in Rodent Trigeminal Primary Afferents
Auteurs : Michael R. Bale [Royaume-Uni, Espagne] ; Dario Campagner [Royaume-Uni] ; Andrew Erskine [Royaume-Uni] ; Rasmus S. Petersen [Royaume-Uni]Source :
- The Journal of Neuroscience [ 0270-6474 ] ; 2015.
Abstract
Communication in the nervous system occurs by spikes: the timing precision with which spikes are fired is a fundamental limit on neural information processing. In sensory systems, spike-timing precision is constrained by first-order neurons. We found that spike-timing precision of trigeminal primary afferents in rats and mice is limited both by stimulus speed and by electrophysiological sampling rate. High-speed video of behaving mice revealed whisker velocities of at least 17,000°/s, so we delivered an ultrafast “ping” (>50,000°/s) to single whiskers and sampled primary afferent activity at 500 kHz. Median spike jitter was 17.4 μs; 29% of neurons had spike jitter < 10 μs. These results indicate that the input stage of the trigeminal pathway has extraordinary spike-timing precision and very high potential information capacity. This timing precision ranks among the highest in biology.
Url:
DOI: 10.1523/JNEUROSCI.3876-14.2015
PubMed: 25878266
PubMed Central: 4397594
Affiliations:
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